Pro-arrhythmic and pro-ischaemic effects of inhaled anticholinergic medications
نویسندگان
چکیده
منابع مشابه
Pro-arrhythmic and pro-ischaemic effects of inhaled anticholinergic medications
The majority of deaths in COPD are from cardiovascular causes. Several large randomized controlled trials demonstrate that inhaled anticholinergic agents ipratropium and tiotropium increase the risk of serious cardiovascular events, including cardiovascular mortality. Tiotropium Respimat is associated with a statistically significant increased risk of mortality (RR 1.52; 95% CI 1.06 to 2.16) an...
متن کاملRepublished: pro-arrhythmic and pro-ischaemic effects of inhaled anticholinergic medications.
The majority of deaths in COPD are from cardiovascular causes. Several large randomized controlled trials demonstrate that inhaled anticholinergic agents ipratropium and tiotropium increase the risk of serious cardiovascular events, including cardiovascular mortality. Tiotropium Respimat is associated with a statistically significant increased risk of mortality (RR 1.52; 95% CI 1.06 to 2.16) an...
متن کاملPro-Arrhythmic Effects of Noncardiac Medications: Lessons From Macrolide Antibiotics.
S udden death resulting from medications prescribed with good intentions is an everpresent threat first recognized nearly a century ago (1,2). As early as 1923, when quinidine was first used as antiarrhythmic therapy, a disturbing phenomenon was noted: some patients treated with quinidine suffered from sudden collapses, sometimes ending in unexpected deaths (2). These events were first attribut...
متن کاملOmega-3 Fatty Acids: Anti-Arrhythmic, Pro-Arrhythmic, or Both?
PURPOSE OF REVIEW Recent publications seem to indicate no or an untoward effect of the marine omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on cardiac rhythm. This review puts these developments into perspective. RECENT FINDINGS In-vitro or in animal models, little pro-arrhythmic effect, but many antiarrhythmic mechanisms of omega-3 fatty acids have been documented. In in...
متن کاملMechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy
INTRODUCTION Hypertrophic cardiomyopathy (HCM) is a cause of sudden arrhythmic death, but the understanding of its pro-arrhythmic mechanisms and an effective pharmacological treatment are lacking. HCM electrophysiological remodelling includes both increased inward and reduced outward currents, but their role in promoting repolarisation abnormalities remains unknown. The goal of this study is to...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Thorax
سال: 2012
ISSN: 0040-6376,1468-3296
DOI: 10.1136/thoraxjnl-2011-201275